Invertebrate vasopressin/oxytocin homologs. Characterization of peptides from Conus geographus and Conus straitus venoms.

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Invertebrate vasopressin/oxytocin homologs. Characterization of peptides from Conus geographus and Conus straitus venoms.

The vasopressin-oxytocin family of peptides is of very ancient lineage, found in organisms as diverse as hydra and man. Although these peptides have been intensively studied in vertebrates, the presumably more extensive invertebrate series was defined primarily by immunological methods. In this report, we describe the purification and structures of two peptides of the vasopressin-oxytocin famil...

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Characterization of the peptidylglycine α-amidating monooxygenase (PAM) from the venom ducts of neogastropods, Conus bullatus and Conus geographus.

Cone snails, genus Conus, are predatory marine snails that use venom to capture their prey. This venom contains a diverse array of peptide toxins, known as conotoxins, which undergo a diverse set of posttranslational modifications. Amidating enzymes modify peptides and proteins containing a C-terminal glycine residue, resulting in loss of the glycine residue and amidation of the preceding resid...

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D-amino acid-containing peptides in Conus venoms

-amino acids have been documented in relatively few gene products, including peptides found in Conus venoms. The present work provides an overview of various D-amino acid-containing Conus peptides (conopeptides or conotoxins), such as the contryphans, conomarphins, conophans, conomap and certain I1-superfamily conotoxins. Characterization of their sequences and structures, as well as the known ...

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Observations on the Feeding Behavior of Conus geographus ( Gastropoda : Toxoglossa )

THE FEEDING BEHAVIOR of various members of the genus Conus has been described (Kohn, 1956a, 1959, 1968; Kline, 1956; Nybakken, 1967). Piscivorous species of Conus, for which feeding behavior has been recorded, attack by extending their proboscises. From this extension a radular tooth used but once is injected into the prey, which is later swallowed. The feeding behavior of Conus geographus Linn...

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Conus venoms: a rich source of novel ion channel-targeted peptides.

The cone snails (genus Conus) are venomous marine molluscs that use small, structured peptide toxins (conotoxins) for prey capture, defense, and competitor deterrence. Each of the 500 Conus can express approximately 100 different conotoxins, with little overlap between species. An overwhelming majority of these peptides are probably targeted selectively to a specific ion channel. Because conoto...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1987

ISSN: 0021-9258

DOI: 10.1016/s0021-9258(18)47661-2